MIPOL1 - meaning and definition. What is MIPOL1
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What (who) is MIPOL1 - definition


MIPOL1         
  • Chromosome 14 diagram with MIPOL1 gene locus marked in red<ref>Hubbard T, Barker D, Birney E, et al. "The Ensembl genome database project." Nucleic Acids Res. 2002;30(1):38-41. [https://pubmed.ncbi.nlm.nih.gov/11752248/ doi:10.1093/nar/30.1.38] </ref>
  • Fig.3. Annotated conceptual translation of MIPOL1 isoform 1 showing the most important features. The underlined parts represent the coiled-coil domains. Bolded amino acids are highly conserved even in orthologs as distant as Cnidarians. Other bracketed regions show conserved protein family regions identified such as COG1196 and COG 4372. Exon boundaries are highlighted in blue. Bipartite nuclear localization signal is highlighted in blue. Parts of the protein absent in other isoforms have been highlighted.
  • Gene neighborhood of MIPOL1
  • Fig.4.Tertiary structure of MIPOL1 generated using I-TASSER:<ref name="I-TASSER">[https://zhanglab.ccmb.med.umich.edu/I-TASSER/ I-TASSER Server for protein structure and function prediction]. Retrieved 20 July 2020 </ref> Blue represents the N-terminus, Red represents the C-terminus
  • Fig.5. Plot of number of amino acid changes per 100 amino acids as a function of date of divergence for MIPOL1, cytochrome c and Fibrinogen alpha
  • Fig.2.Multiple Sequence Alignment of MIPOL1 Orthologs showing conservation of Bipartite Nuclear Localization Signal in Mammalian orthologs (Hsa is human, Lve is Lipotes vexillifer (dolphin), and Mja is Manis javanica (Pangolin)
  • NES]])<ref>Nardozzi, J. D., Lott, K., & Cingolani, G. (2010). Phosphorylation meets nuclear import: a review. Cell communication and signaling : CCS, 8, 32. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022542/ https://doi.org/10.1186/1478-811X-8-32] </ref> O-GlcNACylation site has been highlighted in grey.
PROTEIN-CODING GENE IN THE SPECIES HOMO SAPIENS
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MIPOL1 (Mirror Image Polydactyly 1), also known as CCDC193 (Coiled-coil domain containing 193), is a protein that in humans is encoded by the MIPOL1 gene. NCBI Gene Mirror-Image Polydactyly 1.